A tornado in North Carolina severely damaged a Pfizer plant, damaged several other structures, shut down a major interstate and injured at least four people.

The tornado tore a path of damage through Nash County, around 45 miles northeast of Raleigh, on Wednesday afternoon, initially hitting west of Dortches before crossing Interstate 95 into an area north of Rocky Mount.

At least four people were treated for minor injuries at nearby UNC Health Nash Hospital, a spokesperson told CNN.

Some structures in the tornado's path were completely flattened. Pfizer's Rocky Mount facility suffered severe damage from the tornado -- video from helicopters showed the roof crumpled like paper and building debris scattered into the surrounding parking lot. There were no reports of injuries at the plant, according to a statement from the company.

"We are assessing the situation to determine the impact on production. Our thoughts are with our colleagues, our patients, and the community as we rebuild from this weather incident," the statement said.

Nash County Sheriff Keith Stone urged people to stay off roads because of downed power lines, a gas leak and other severe damage across the area.

"It's still a dangerous situation, we're trying to get as much of this cleaned up before nightfall," Stone told CNN affiliate WRAL.

The tornado toppled trees onto Interstate 95, the North Carolina Department of Transportation said, shutting the highway down in both directions for at least an hour before later reopening.

North Carolina Gov. Roy Cooper acknowledged the damage on Twitter and said that first responders were on scene helping clear roads and provide other aid.

The National Weather Service will send out survey teams this afternoon to assess the damage and confirm the tornado's strength.

This is a developing story and will be updated.