The San Francisco Giants and Minnesota Twins will face off in a matinee matchup on Wednesday in Minnesota with two hot starters on the mound.

Joe Ryan (6-1, 2.25 ERA) gets the ball for the Twins, and he's looking to build on an early Cy Young caliber line this season. He will be opposed by Anthony DeSclafani (3-3, 3.09 ERA) who has been solid in his own right to open the 2023 season.

The Twins come into this game in first place in the AL Central, but they are still hovering around .500 record wise. Can they pick up a seventh win in Ryan's starts this season?

Let's break down the odds and a best bet for this game:

Giants vs. Twins odds, run line and total

Giants vs. Twins prediction and pick

The Twins are 6-3 in Ryan's nine starts this season, and I like them to win this game, but not because of the starting pitching advantage.

I actually trust DeSclafani to keep this close early, as he's allowed three or fewer runs in seven of his nine starts, but the Giants' bullpen is the major question mark in this game.

San Francisco ranks 28th in MLB in bullpen ERA, giving Minnesota's No. 11 bullpen a huge advantage.

Ryan's 2.25 ERA is supported by an impressive 2.34 Fielding Independent Pitching (FIP). so I expect him to keep the Giants in check offensively. San Francisco has hit right-handed pitching well, but so have the Twins, both ranking in the top half of the league in OPS against righties.

Back Ryan and the Twins bullpen to get the win at home on Wednesday afternoon.

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Game odds refresh periodically and are subject to change.